MATAO-A clinical phase III trial on the use of letrozole maintenance therapy for newly diagnosed advanced ovarian, fallopian tube or peritoneal cancers.

In Switzerland, every year, around 800 women are diagnosed with ovarian, fallopian tube or peritoneal cancer. The prognosis of patients with advanced ovarian/tubal/peritoneal cancer is poor with over 70% of patients diagnosed with progression within 3 years of initial diagnosis and a 5-year overall survival rate reported varying from 30% till up to 50%, emphasizing the clear unmet medical need for new treatment modalities. A high percentage of the epithelial ovarian cancers express Estrogen Receptor (ER), an ideal target for endocrine therapy. Letrozole, in this respect, has been used for over decade now to treat Estrogen Receptor positive breast cancer and preliminary results demonstrate it can be a potent drug for patients with heavily pre-treated ovarian cancer as well. However, it has not been evaluated for its use in the maintenance setting for ovarian cancer after standard of care till now. The MATAO trial aims to evaluate the use of letrozole in the maintenance setting as additional standard of care for ovarian cancer patients.

MATAO- MAintenance Therapy with Aromatase inhibitor in epithelial Ovarian cancer: a randomized double-blinded placebo-controlled multi-center phase III Trial including LOGOS (LOw Grade Ovarian cancer Sub-study) (ENGOT-ov54/Swiss-GO-2)

Are you just diagnosed with or does your patient belong to this group with newly diagnosed ovarian, fallopian tube or peritoneal cancer, and would you or your patient like to participate in this study?

Join in!

Recruitement:

Until the end of January 2023, 251 patients had been recruited and 124 randomized into the trial! Thanks to Austrian sites joining, the recruitment rate boosted around 10%, thank you!